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Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.
Nishina, Takashi; Deguchi, Yutaka; Ohshima, Daisuke; Takeda, Wakami; Ohtsuka, Masato; Shichino, Shigeyuki; Ueha, Satoshi; Yamazaki, Soh; Kawauchi, Mika; Nakamura, Eri; Nishiyama, Chiharu; Kojima, Yuko; Adachi-Akahane, Satomi; Hasegawa, Mizuho; Nakayama, Mizuho; Oshima, Masanobu; Yagita, Hideo; Shibuya, Kazutoshi; Mikami, Tetuo; Inohara, Naohiro; Matsushima, Kouji; Tada, Norihiro; Nakano, Hiroyasu.
Afiliación
  • Nishina T; Department of Biochemistry, Toho University School of Medicine, Tokyo, Japan. takashi.nishina@med.toho-u.ac.jp.
  • Deguchi Y; Department of Biochemistry, Toho University School of Medicine, Tokyo, Japan.
  • Ohshima D; Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
  • Takeda W; Department of Biochemistry, Toho University School of Medicine, Tokyo, Japan.
  • Ohtsuka M; Laboratory of Molecular Biology and Immunology, Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Tokyo, Japan.
  • Shichino S; Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Kanagawa, Japan.
  • Ueha S; The Institute of Medical Sciences, Tokai University, Isehara, Kanagawa, Japan.
  • Yamazaki S; Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
  • Kawauchi M; Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
  • Nakamura E; Department of Biochemistry, Toho University School of Medicine, Tokyo, Japan.
  • Nishiyama C; Department of Biochemistry, Toho University School of Medicine, Tokyo, Japan.
  • Kojima Y; Research Institute for Diseases of Old Age, Juntendo University School of Medicine, Tokyo, Japan.
  • Adachi-Akahane S; Laboratory of Molecular Biology and Immunology, Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Tokyo, Japan.
  • Hasegawa M; Laboratory of Morphology and Image Analysis, Research Support Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Nakayama M; Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
  • Oshima M; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Yagita H; WPI Nano Life Science Institute (WPI-Nano LSI), Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
  • Shibuya K; WPI Nano Life Science Institute (WPI-Nano LSI), Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
  • Mikami T; Department of Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Inohara N; Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan.
  • Matsushima K; Department of Pathology, Toho University School of Medicine, Tokyo, Japan.
  • Tada N; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Nakano H; Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
Nat Commun ; 12(1): 2281, 2021 04 16.
Article en En | MEDLINE | ID: mdl-33863879
Interleukin (IL)-11 is a member of the IL-6 family of cytokines and is involved in multiple cellular responses, including tumor development. However, the origin and functions of IL-11-producing (IL-11+) cells are not fully understood. To characterize IL-11+ cells in vivo, we generate Il11 reporter mice. IL-11+ cells appear in the colon in murine tumor and acute colitis models. Il11ra1 or Il11 deletion attenuates the development of colitis-associated colorectal cancer. IL-11+ cells express fibroblast markers and genes associated with cell proliferation and tissue repair. IL-11 induces the activation of colonic fibroblasts and epithelial cells through phosphorylation of STAT3. Human cancer database analysis reveals that the expression of genes enriched in IL-11+ fibroblasts is elevated in human colorectal cancer and correlated with reduced recurrence-free survival. IL-11+ fibroblasts activate both tumor cells and fibroblasts via secretion of IL-11, thereby constituting a feed-forward loop between tumor cells and fibroblasts in the tumor microenvironment.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenoma / Interleucina-11 / Colitis / Fibroblastos / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenoma / Interleucina-11 / Colitis / Fibroblastos / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Japón