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High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.
Choi, Ryan; Zhou, Mowei; Shek, Roger; Wilson, Jesse W; Tillery, Logan; Craig, Justin K; Salukhe, Indraneel A; Hickson, Sarah E; Kumar, Neeraj; James, Rhema M; Buchko, Garry W; Wu, Ruilian; Huff, Sydney; Nguyen, Tu-Trinh; Hurst, Brett L; Cherry, Sara; Barrett, Lynn K; Hyde, Jennifer L; Van Voorhis, Wesley C.
Afiliación
  • Choi R; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
  • Zhou M; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
  • Shek R; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
  • Wilson JW; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
  • Tillery L; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
  • Craig JK; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
  • Salukhe IA; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
  • Hickson SE; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
  • Kumar N; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
  • James RM; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.
  • Buchko GW; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.
  • Wu R; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
  • Huff S; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
  • Nguyen TT; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
  • Hurst BL; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
  • Cherry S; School of Molecular Bioscience, Washington State University, Pullman, WA, United States of America.
  • Barrett LK; Bioenergy and Biome Sciences, Los Alamos National Laboratory (LANL), Los Alamos, NM, United States of America.
  • Hyde JL; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
  • Van Voorhis WC; Calibr, a division of The Scripps Research Institute, La Jolla, CA, United States of America.
PLoS One ; 16(4): e0250019, 2021.
Article en En | MEDLINE | ID: mdl-33886614
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Proteínas no Estructurales Virales / Endorribonucleasas / Bibliotecas de Moléculas Pequeñas / Reposicionamiento de Medicamentos / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Proteínas no Estructurales Virales / Endorribonucleasas / Bibliotecas de Moléculas Pequeñas / Reposicionamiento de Medicamentos / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos