[Factors affecting the recovery of cholinesterase activity in patients with acute chlorpyrifos poisoning].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 39(4): 286-288, 2021 Apr 20.
Article
en Zh
| MEDLINE
| ID: mdl-33910290
ABSTRACT
Objective:
To investigate the related factors affecting the recovery of cholinesterase (ChE) activity in patients with acute chlorpyrifos poisoning.Methods:
In February 2020, the clinical data of acute chlorpyrifos poisoning patients admitted in our hospital from January 2016 to December 2019 were retrospectively analyzed. The outcome variable was the time of ChE activity recovered to 50% lower limit of normal value, and multivariate linear regression analysis was performed to explore its influencing factors.Results:
A total of 78 patients, 43 males and 35 females, with an average age (39.58±14.77) years were enrolled in this study. The average time of serum ChE activity recovered to 50% lower limit of normal value was (24.45±2.64) days. There was a correlation between hemoperfusion (r=-0.644) , atropine dosage (r=0.498) , chlorophosphorus dosage (r=0.432) and the time of serum ChE activity recovered to 50% lower limit of normal value, in which hemoperfusion was significantly negatively correlated with the time of serum ChE activity recovered to 50% lower limit of normal value (ß=-4.222, P<0.05) .Conclusion:
The recovery of serum ChE activity in patients with acute chlorpyrifos poisoning is very slow. Hemoperfusion can quickly remove chlorpyrifos, its metabolites and inflammatory mediators in the blood, thus effectively promoting the recovery of ChE activity.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cloropirifos
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Female
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Humans
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Male
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Middle aged
Idioma:
Zh
Revista:
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
Asunto de la revista:
MEDICINA OCUPACIONAL
Año:
2021
Tipo del documento:
Article
País de afiliación:
China