Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage.
Exp Neurol
; 342: 113736, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-33945790
ABSTRACT
Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic deficits such as cognitive disabilities. Recently, the intraventricular transplantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (MSCs) has drawn attention as a therapeutic potential to treat severe IVH. However, its pathological synaptic mechanism is still elusive. We here demonstrated that the integration of the somatosensory input was significantly distorted by suppressing feed-forward inhibition (FFI) at the thalamocortical (TC) inputs in the barrel cortices of neonatal rats with IVH by using BOLD-fMRI signal and brain slice patch-clamp technique. This is induced by the suppression of Hebbian plasticity via an increase in tumor necrosis factor-α expression during the critical period, which can be effectively reversed by the transplantation of MSCs. Furthermore, we showed that MSC transplantation successfully rescued IVH-induced learning deficits in the sensory-guided decision-making in correlation with TC FFI in the layer 4 barrel cortex.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tálamo
/
Corteza Cerebral
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Trasplante de Células Madre Mesenquimatosas
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Disfunción Cognitiva
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Hemorragia Cerebral Intraventricular
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Plasticidad Neuronal
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
/
Male
Idioma:
En
Revista:
Exp Neurol
Año:
2021
Tipo del documento:
Article