Phosphate meeting cholesterol-consequences for cardiovascular disease in chronic kidney disease?
Kidney Int
; 99(6): 1264-1267, 2021 06.
Article
en En
| MEDLINE
| ID: mdl-34023025
ABSTRACT
Cardiovascular disease is highly prevalent in patients with chronic kidney disease. Hyperphosphatemia is associated with subclinical atheromatosis in chronic kidney disease. Phosphate-induced endothelial dysfunction and vascular calcification are thought to be key inducers of atherosclerosis in this condition. Zhou et al. now demonstrate that phosphate promotes de novo cholesterol synthesis in vascular smooth muscle and macrophages through increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activation. This observation may change current concepts of atherosclerosis development and management in chronic kidney disease.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Insuficiencia Renal Crónica
/
Aterosclerosis
/
Hiperfosfatemia
/
Calcificación Vascular
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Kidney Int
Año:
2021
Tipo del documento:
Article