DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A.

Leon, Kelly E; Buj, Raquel; Lesko, Elizabeth; Dahl, Erika S; Chen, Chi-Wei; Tangudu, Naveen Kumar; Imamura-Kawasawa, Yuka; Kossenkov, Andrew V; Hobbs, Ryan P; Aird, Katherine M

Leon, Kelly E; Buj, Raquel; Lesko, Elizabeth; Dahl, Erika S; Chen, Chi-Wei; Tangudu, Naveen Kumar; Imamura-Kawasawa, Yuka; Kossenkov, Andrew V; Hobbs, Ryan P; Aird, Katherine M.

Afiliación

Leon KE; Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Buj R; Biomedical Sciences Graduate Program, Penn State College of Medicine, Hershey, PA.
Lesko E; Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Dahl ES; Department of Dermatology, Penn State College of Medicine, Hershey, PA.
Chen CW; Biomedical Sciences Graduate Program, Penn State College of Medicine, Hershey, PA.
Tangudu NK; Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Imamura-Kawasawa Y; Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Kossenkov AV; Department of Pharmacology, Penn State College of Medicine, Hershey, PA.
Hobbs RP; The Wistar Institute, Philadelphia, PA.
Aird KM; Department of Dermatology, Penn State College of Medicine, Hershey, PA.

J Cell Biol ; 220(8)2021 08 02.

Article en En | MEDLINE | ID: mdl-34037658

Asunto(s)

Senescencia Celular; Metilación de ADN; Epigénesis Genética; Fibroblastos/enzimología; N-Metiltransferasa de Histona-Lisina/metabolismo; Histonas/metabolismo; Interleucina-1alfa/metabolismo; 9,10-Dimetil-1,2-benzantraceno; Animales; Proteína beta Potenciadora de Unión a CCAAT/genética; Proteína beta Potenciadora de Unión a CCAAT/metabolismo; Puntos de Control del Ciclo Celular; Proliferación Celular; Femenino; Células HEK293; N-Metiltransferasa de Histona-Lisina/genética; Histonas/genética; Humanos; Interleucina-1alfa/genética; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Ratones; Microscopía Fluorescente; Papiloma/inducido químicamente; Papiloma/genética; Papiloma/metabolismo; Papiloma/patología; Fenotipo; Vías Secretoras; Neoplasias Cutáneas/inducido químicamente; Neoplasias Cutáneas/genética; Neoplasias Cutáneas/metabolismo; Neoplasias Cutáneas/patología; Acetato de Tetradecanoilforbol

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Histonas / N-Metiltransferasa de Histona-Lisina / Senescencia Celular / Metilación de ADN / Epigénesis Genética / Interleucina-1alfa / Fibroblastos Tipo de estudio: Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: J Cell Biol Año: 2021 Tipo del documento: Article País de afiliación: Panamá

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