Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.

Nanou, Aikaterini; Bourbouli, Mara; Vetrano, Stefania; Schaeper, Ute; Ley, Steven; Kollias, George

Nanou, Aikaterini; Bourbouli, Mara; Vetrano, Stefania; Schaeper, Ute; Ley, Steven; Kollias, George.

Afiliación

Nanou A; Institute for Bioinnovation, Biomedical Science Research Center (BSRC) "Alexander Fleming," Vari, Attika, Greece.
Bourbouli M; Institute for Bioinnovation, Biomedical Science Research Center (BSRC) "Alexander Fleming," Vari, Attika, Greece.
Vetrano S; Department of Biomedical Sciences, Humanitas University, Rozzano, Italy; IBD Center, Humanitas Research Hospital, Rozzano, Italy.
Schaeper U; Silence Therapeutics GmbH, Berlin, Germany.
Ley S; Immune Cell Signalling Laboratory, The Francis Crick Institute, London, UK; Imperial College, London, UK.
Kollias G; Institute for Bioinnovation, Biomedical Science Research Center (BSRC) "Alexander Fleming," Vari, Attika, Greece; Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: geokollias@med.uoa.gr.

Cell Rep ; 35(8): 109168, 2021 05 25.

Article en En | MEDLINE | ID: mdl-34038728

Asunto(s)

Claudina-5/metabolismo; Células Endoteliales/metabolismo; Inflamación/genética; Quinasas Quinasa Quinasa PAM/metabolismo; Proteínas Proto-Oncogénicas/metabolismo; Animales; Humanos; Ratones; Metástasis de la Neoplasia

Palabras clave

Claudin-5; EAE; JNK; MAP3K8; Occludin; Tpl2; endothelial; lung metastasis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Quinasas Quinasa Quinasa PAM / Células Endoteliales / Claudina-5 / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article País de afiliación: Grecia

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