Risk factors for the emergence of multidrug-resistant organisms in liver cirrhosis.
Gastroenterol Hepatol
; 45(3): 186-191, 2022 Mar.
Article
en En, Es
| MEDLINE
| ID: mdl-34052400
ABSTRACT
BACKGROUND:
Multidrug-resistant organisms (MDROs) are a reality that can alter the paradigm of treatment and prevention of infection in patients with liver cirrhosis (LC).OBJECTIVE:
Identify risk factors for the occurrence of MDROs in patients with LC. PATIENTS ANDMETHODS:
Prospective study from October 2017 to March 2018 in consecutively hospitalized patients with decompensated LC with infection. Blood, urine and ascitic fluid cultures were analyzed. A p-value ≤0.05 was considered statistically significant.RESULTS:
MDROs isolated in 18 of 52 episodes of infection. MDROs were associated with the use of proton pump inhibitors (PPIs) (p=0.0312), antibiotic therapy in the last 90 days (p=0.0033) and discharge within preceding 30 days or current hospitalization above 48h (p=0.0082). There was higher 90-day mortality in patients with MDROs infection (71.4% versus 35.7%, p=0.0316).CONCLUSION:
MDROs infections were prevalent in this cohort and associated with 90-day mortality. Use of PPIs and antibiotics increased the risk of MDROs infections, suggesting that its prescription should be restricted to formal indication. Hospitalization was associated with the onset of MDROs, so LC patients should stay at the hospital the least possible. It is relevant to investigate other factors predisposing to the emergence of these microorganisms, in order to prevent it.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Infecciones Bacterianas
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Infección Hospitalaria
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Farmacorresistencia Bacteriana Múltiple
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Cirrosis Hepática
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
/
Es
Revista:
Gastroenterol Hepatol
Año:
2022
Tipo del documento:
Article