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Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry.
Guilinger, John P; Archna, Archna; Augustin, Martin; Bergmann, Andreas; Centrella, Paolo A; Clark, Matthew A; Cuozzo, John W; Däther, Maike; Guié, Marie-Aude; Habeshian, Sevan; Kiefersauer, Reiner; Krapp, Stephan; Lammens, Alfred; Lercher, Lukas; Liu, Julie; Liu, Yanbin; Maskos, Klaus; Mrosek, Michael; Pflügler, Klaus; Siegert, Markus; Thomson, Heather A; Tian, Xia; Zhang, Ying; Konz Makino, Debora L; Keefe, Anthony D.
Afiliación
  • Guilinger JP; X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA. Electronic address: jguilinger@x-chemrx.com.
  • Archna A; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Augustin M; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Bergmann A; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Centrella PA; X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA.
  • Clark MA; X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA.
  • Cuozzo JW; ZebiAI Inc., 100 Beaver Street, Waltham, MA 02453, USA.
  • Däther M; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Guié MA; X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA.
  • Habeshian S; Laboratory of Therapeutic Proteins and Peptides École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Kiefersauer R; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Krapp S; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Lammens A; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Lercher L; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Liu J; Accent Therapeutics Inc., 65 Hayden Avenue, Lexington, MA 02421, USA.
  • Liu Y; Cyteir Therapeutics, 128 Spring St, Lexington, MA 02421, USA.
  • Maskos K; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Mrosek M; Bruker AXS GmbH, Karlsruhe, Germany.
  • Pflügler K; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Siegert M; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany.
  • Tian X; Nurix Therapeutics Inc., 1700 Owens Street, Suite 205 San Francisco, CA 94158, USA.
  • Zhang Y; X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA.
  • Konz Makino DL; Proteros biostructures GmbH, Bunsenstr. 7a, 82152 Planegg-Martinsried, Germany. Electronic address: konz-makino@proteros.de.
  • Keefe AD; X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA. Electronic address: akeefe@x-chemrx.com.
Bioorg Med Chem ; 42: 116223, 2021 07 15.
Article en En | MEDLINE | ID: mdl-34091303
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN / Inhibidores de Proteínas Quinasas / Bibliotecas de Moléculas Pequeñas / Descubrimiento de Drogas / Agammaglobulinemia Tirosina Quinasa Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN / Inhibidores de Proteínas Quinasas / Bibliotecas de Moléculas Pequeñas / Descubrimiento de Drogas / Agammaglobulinemia Tirosina Quinasa Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article