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Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status.
Nerpin, Elisabet; Ferreira, Diogenes Seraphim; Weyler, Joost; Schlunnsen, Vivi; Jogi, Rain; Raherison Semjen, Chantal; Gislasson, Thorainn; Demoly, Pascal; Heinrich, Joachim; Nowak, Dennis; Corsico, Angelo; Accordini, Simone; Marcon, Alessandro; Squillacioti, Giulia; Olivieri, Mario; Nielsen, Rune; Johannessen, Ane; Gómez Real, Francisco; Garcia-Aymerich, Judith; Urrutia, Isabel; Pereira-Vega, Antonio; Gullón, Jose Antonio; Olin, Anna-Carin; Forsberg, Bertil; Emilsson, Össur Ingi; Pin, Isabelle; Jarvis, Deborah; Janson, Christer; Malinovschi, Andrei.
Afiliación
  • Nerpin E; Department of Medical Sciences, Respiratory Medicine, Allergy and Sleep, Uppsala University, Uppsala, Sweden.
  • Ferreira DS; Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
  • Weyler J; Department of Medicine, Health and Social Studies, Dalarna University, Falun, Sweden.
  • Schlunnsen V; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Melbourne, Australia.
  • Jogi R; Alergia e Imunologia, Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil.
  • Raherison Semjen C; Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium.
  • Gislasson T; Department of Environment Occupation & Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
  • Demoly P; Lung Clinic, Tartu University Hospital, Tartu, Estonia.
  • Heinrich J; U1219, Bordeaux Population Health Research Center, Bordeaux, France.
  • Nowak D; Department of Sleep, Landspitali University Hospital, Reykjavik, Iceland.
  • Corsico A; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  • Accordini S; Département de Pneumologie et Addictologie, Centre Hospitalier Universitaire de Montpellier, Hopital Arnaud de Villeneuve, Univ Montpellier, Montpellier, France.
  • Marcon A; Institut Pierre-Louis D'épidémiologie et de Santé Publique, Équipe EPAR, Sorbonne Université, INSERM, Paris, France.
  • Squillacioti G; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital Munich, Ludwig Maximilians University Munich, Munich, Germany.
  • Olivieri M; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Nielsen R; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
  • Johannessen A; Hospital of the Ludwig-Maximilian University Munich, LMU Munich, Munich, Germany.
  • Gómez Real F; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany.
  • Garcia-Aymerich J; Division of Respiratory Diseases, Medical Sciences and Infectious Diseases Department, IRCCS Policlinico San Matteo Foundation.
  • Urrutia I; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
  • Pereira-Vega A; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Gullón JA; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Olin AC; Department of Public Health and Pediatrics - University of Turin, Turin, Italy.
  • Forsberg B; Unit of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Emilsson ÖI; Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.
  • Pin I; Department of Clinical Science, University of Bergen, Bergen, Norway.
  • Jarvis D; Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway.
  • Janson C; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.
  • Malinovschi A; Department of Clinical Science, University of Bergen, Bergen, Norway.
World Allergy Organ J ; 14(5): 100544, 2021 May.
Article en En | MEDLINE | ID: mdl-34093956
BACKGROUND: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations. OBJECTIVES: To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. METHODS: Longitudinal analyses of previous lung function decline and FeNO level at follow-up and cross-sectional analyses of BD response and FeNO levels in 4257 participants (651 asthmatics) from the European Community Respiratory Health Survey. RESULTS: Among asthmatic subjects, higher percentage declines of FEV1 and FEV1/FVC were associated with higher FeNO levels (p = 0.001 for both) at follow-up. These correlations were found mainly among non-smoking individuals (p = 0.001) and females (p = 0.001) in stratified analyses.Percentage increase in FEV1 after BD was positively associated with FeNO levels in non-asthmatic subjects. Further, after stratified for sex and smoking separately, a positive association was seen between FEV1 and FeNO levels in non-smokers and women, regardless of asthma status. CONCLUSIONS: We found a relationship between elevated FeNO and larger FEV1 decline over 20 years among subjects with asthma who were non-smokers or women. The association between elevated FeNO levels and larger BD response was found in both non-asthmatic and asthmatic subjects, mainly in women and non-smoking subjects.
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: World Allergy Organ J Año: 2021 Tipo del documento: Article País de afiliación: Suecia

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: World Allergy Organ J Año: 2021 Tipo del documento: Article País de afiliación: Suecia