Potential Non-invasive Brain Stimulation Targets to Alleviate Freezing of Gait in Parkinson's Disease.
Neuroscience
; 468: 366-376, 2021 08 01.
Article
en En
| MEDLINE
| ID: mdl-34102265
ABSTRACT
Freezing of gait (FOG) is a common motor symptom in Parkinson's disease (PD). Although FOG reduces quality of life, affects mobility and increases the risk of falls, there are little to no effective treatments to alleviate FOG. Non-invasive brain stimulation (NIBS) has recently yielded attention as a potential treatment to reduce FOG symptoms however, stimulation parameters and protocols remain inconsistent and require further research. Specifically, targets for stimulation require careful review. Thus, with current neuroimaging and neuro-electrophysiological evidence, we consider potential cortical targets thought to be involved in the pathophysiology of FOG according to the Interference model, and within reach of NIBS. We note that the primary motor cortex, the supplementary motor area and the dorsolateral prefrontal cortex have already drawn attention as NIBS targets for FOG, but based on neuroimaging evidence the premotor cortex, the medial prefrontal cortex, the cerebellum, and more particularly, the posterior parietal cortex should be considered as potential regions for stimulation. We also discuss different methodological considerations, such as stimulation type, medication state, and hemisphere to target, and future perspectives for NIBS protocols in FOG.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Trastornos Neurológicos de la Marcha
/
Corteza Motora
Tipo de estudio:
Etiology_studies
/
Guideline
Límite:
Humans
Idioma:
En
Revista:
Neuroscience
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá