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Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia.
Braun, Urs; Harneit, Anais; Pergola, Giulio; Menara, Tommaso; Schäfer, Axel; Betzel, Richard F; Zang, Zhenxiang; Schweiger, Janina I; Zhang, Xiaolong; Schwarz, Kristina; Chen, Junfang; Blasi, Giuseppe; Bertolino, Alessandro; Durstewitz, Daniel; Pasqualetti, Fabio; Schwarz, Emanuel; Meyer-Lindenberg, Andreas; Bassett, Danielle S; Tost, Heike.
Afiliación
  • Braun U; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. urs.braun@zi-mannheim.de.
  • Harneit A; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. urs.braun@zi-mannheim.de.
  • Pergola G; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Menara T; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Schäfer A; Mechanical Engineering Department, University of California at Riverside, Riverside, CA, USA.
  • Betzel RF; Bender Institute of Neuroimaging, Justus Liebig University Giessen, Gießen, Germany.
  • Zang Z; Center for Mind, Brain and Behavior, University of Marburg and Justus Liebig University Giessen, Gießen, Germany.
  • Schweiger JI; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
  • Zhang X; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Schwarz K; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Chen J; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Blasi G; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Bertolino A; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Durstewitz D; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Pasqualetti F; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Schwarz E; Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Meyer-Lindenberg A; Mechanical Engineering Department, University of California at Riverside, Riverside, CA, USA.
  • Bassett DS; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Tost H; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Nat Commun ; 12(1): 3478, 2021 06 09.
Article en En | MEDLINE | ID: mdl-34108456
ABSTRACT
Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory performance entails brain-wide switching between activity states using a combination of functional magnetic resonance imaging in healthy controls and individuals with schizophrenia, pharmacological fMRI, genetic analyses and network control theory. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Individuals with schizophrenia show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations. Our results demonstrate the relevance of dopamine signaling for the steering of whole-brain network dynamics during working memory and link these processes to schizophrenia pathophysiology.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Esquizofrenia / Encéfalo / Memoria a Corto Plazo / Red Nerviosa Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Esquizofrenia / Encéfalo / Memoria a Corto Plazo / Red Nerviosa Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania