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The membrane-targeting mechanism of host defense peptides inspiring the design of polypeptide-conjugated gold nanoparticles exhibiting effective antibacterial activity against methicillin-resistant Staphylococcus aureus.
Zhang, Weiwei; Wu, Yueming; Liu, Longqiang; Xiao, Ximian; Cong, Zihao; Shao, Ning; Qiao, Zhongqian; Chen, Kang; Liu, Shiqi; Zhang, Haodong; Ji, Zhemin; Shao, Xiaoyan; Dai, Yidong; He, Hongyan; Xia, Jiang; Fei, Jian; Liu, Runhui.
Afiliación
  • Zhang W; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China. rliu@ecust.edu.cn.
  • Wu Y; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China. rliu@ecust.edu.cn.
  • Liu L; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Xiao X; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Cong Z; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Shao N; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Qiao Z; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Chen K; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Liu S; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Zhang H; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Ji Z; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Shao X; Shanghai Ruijin Rehabilitation Hospital, Shanghai 200023, China.
  • Dai Y; Shanghai Ruijin Rehabilitation Hospital, Shanghai 200023, China.
  • He H; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
  • Xia J; Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
  • Fei J; Department of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Liu R; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China. rliu@ecust.edu.cn and Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biome
J Mater Chem B ; 9(25): 5092-5101, 2021 06 30.
Article en En | MEDLINE | ID: mdl-34128037
Multidrug-resistant bacterial infections are a grand challenge to global medical and health systems. Therefore, it is urgent to develop versatile antibacterial strategies that can combat bacterial resistance without displaying toxicity. Here, we synthesize antibacterial polypeptide-conjugated gold nanoparticles that exhibit potent antibacterial activities against clinically isolated multiple drug resistance Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus, and excellent in vitro and in vivo biocompatibility. The antibacterial mechanism study indicates that over-production of reactive oxygen species results in the killing of bacteria. The overall antibacterial performance of these polypeptide-conjugated gold nanoparticles and the convenient synthesis of these polypeptides via lithium hexamethyldisilazide-initiated fast ring-opening polymerization on α-amino acid N-carboxyanhydride imply the potential application of this strategy in treating bacterial infections.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Nanopartículas del Metal / Staphylococcus aureus Resistente a Meticilina / Oro / Antibacterianos Idioma: En Revista: J Mater Chem B Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Nanopartículas del Metal / Staphylococcus aureus Resistente a Meticilina / Oro / Antibacterianos Idioma: En Revista: J Mater Chem B Año: 2021 Tipo del documento: Article País de afiliación: China