Platelet decrease and efficacy of platelet-rich plasma return following peripheral blood stem cell apheresis.
J Clin Apher
; 36(5): 687-696, 2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-34133767
ABSTRACT
BACKGROUND:
Peripheral blood stem cell (PBSC) transplantation is a key treatment option for hematological diseases and is widely performed in clinical practice. Platelet loss is one of the major complications of PBSC apheresis, and platelet-rich plasma (PRP) return is considered in case of platelet decrease following apheresis; however, little is known about the frequency and severity of platelet loss and the efficacy of PRP return postapheresis.METHODS:
We assessed changes in platelet counts following PBSC-related apheresis in 270 allogeneic (allo)- and 105 autologous (auto)-PBSC settings. We also evaluated the efficacy of PRP transfusion on platelet recovery postapheresis.RESULTS:
In both allo- and auto-PBSC settings, the preapheresis platelet count (range, 84-385 and 33-558 × 109 /L, respectively) decreased postapheresis (range, 57-292 and 20-429 × 109 /L, respectively), whereas severe platelet decrease (<50 × 109 /L) was only observed in auto-PBSC patients (n = 9). We confirmed that platelet count before apheresis was a risk factor for severe platelet decrease (<50 × 109 /L) following auto-PBSC apheresis (odds ratio 0.749, P < .049). PRP return postapheresis facilitated platelet recovery in more than 80% of cases in both allo and auto settings.CONCLUSION:
Lower platelet count preapheresis is a useful predictor of severe platelet decrease following auto-PBSC apheresis and PRP return is an effective process to facilitate platelet recovery postapheresis.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Eliminación de Componentes Sanguíneos
/
Trasplante de Células Madre de Sangre Periférica
/
Plasma Rico en Plaquetas
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Clin Apher
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón