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SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma.
Yuan, Lu; Wu, Xixi; Zhang, Longshan; Yang, Mi; Wang, Xiaoqing; Huang, Wenqi; Pan, Hua; Wu, Yuting; Huang, Jihong; Liang, Wenyu; Li, Jiaxin; Zhu, Xiaodi; Wang, Shuang; Guan, Jian; Liu, Laiyu.
Afiliación
  • Yuan L; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Wu X; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Zhang L; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Yang M; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Wang X; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Huang W; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Pan H; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Wu Y; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Huang J; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Liang W; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Li J; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Zhu X; Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Wang S; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. shuangw@126.com.
  • Guan J; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. shuangw@126.com.
  • Liu L; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. guanjian5461@163.com.
Cancer Immunol Immunother ; 71(2): 399-415, 2022 Feb.
Article en En | MEDLINE | ID: mdl-34181042
Pulmonary surfactant protein A1 (SFTPA1) is a member of the C-type lectin subfamily that plays a critical role in maintaining lung tissue homeostasis and the innate immune response. SFTPA1 disruption can cause several acute or chronic lung diseases, including lung cancer. However, little research has been performed to associate SFTPA1 with immune cell infiltration and the response to immunotherapy in lung cancer. The findings of our study describe the SFTPA1 expression profile in multiple databases and was validated in BALB/c mice, human tumor tissues, and paired normal tissues using an immunohistochemistry assay. High SFTPA1 mRNA expression was associated with a favorable prognosis through a survival analysis in lung adenocarcinoma (LUAD) samples from TCGA. Further GeneOntology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses showed that SFTPA1 was involved in the toll-like receptor signaling pathway. An immune infiltration analysis clarified that high SFTPA1 expression was associated with an increased number of M1 macrophages, CD8+ T cells, memory activated CD4+ T cells, regulatory T cells, as well as a reduced number of M2 macrophages. Our clinical data suggest that SFTPA1 may serve as a biomarker for predicting a favorable response to immunotherapy for patients with LUAD. Collectively, our study extends the expression profile and potential regulatory pathways of SFTPA1 and may provide a potential biomarker for establishing novel preventive and therapeutic strategies for lung adenocarcinoma.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfocitos Infiltrantes de Tumor / Linfocitos T Reguladores / Proteína A Asociada a Surfactante Pulmonar / Microambiente Tumoral / Adenocarcinoma del Pulmón / Inmunoterapia / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Cancer Immunol Immunother Asunto de la revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfocitos Infiltrantes de Tumor / Linfocitos T Reguladores / Proteína A Asociada a Surfactante Pulmonar / Microambiente Tumoral / Adenocarcinoma del Pulmón / Inmunoterapia / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Cancer Immunol Immunother Asunto de la revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: China