A Novel Fluorescent Probe for Hydrogen Peroxide and Its Application in Bio-Imaging.
Molecules
; 26(11)2021 Jun 02.
Article
en En
| MEDLINE
| ID: mdl-34199465
ABSTRACT
Hydrogen peroxide (H2O2) plays an important role in the human body and monitoring its level is meaningful due to the relationship between its level and diseases. A fluorescent sensor (CMB) based on coumarin was designed and its ability for detecting hydrogen peroxide by fluorescence signals was also studied. The CMB showed an approximate 25-fold fluorescence enhancement after adding H2O2 due to the interaction between the CMB and H2O2 and had the potential for detecting physiological H2O2. It also showed good biocompatibility and permeability, allowing it to penetrate cell membranes and zebrafish tissues, thus it can perform fluorescence imaging of H2O2 in living cells and zebrafish. This probe is a promising tool for monitoring the level of H2O2 in related physiological and pathological research.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cumarinas
/
Colorantes Fluorescentes
/
Peróxido de Hidrógeno
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China