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A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer.
Palit, Sander A L; van Dorp, Jeroen; Vis, Daniel; Lieftink, Cor; Linder, Simon; Beijersbergen, Roderick; Bergman, Andries M; Zwart, Wilbert; van der Heijden, Michiel S.
Afiliación
  • Palit SAL; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. s.palit@nki.nl.
  • van Dorp J; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
  • Vis D; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Lieftink C; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
  • Linder S; NKI Robotics and Screening Center and ScreeninC, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Beijersbergen R; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Bergman AM; Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Zwart W; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
  • van der Heijden MS; NKI Robotics and Screening Center and ScreeninC, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Sci Rep ; 11(1): 13683, 2021 07 01.
Article en En | MEDLINE | ID: mdl-34211036
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Feniltiohidantoína / Neoplasias de la Próstata / Benzamidas / Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas B-raf / Antineoplásicos / Nitrilos Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Feniltiohidantoína / Neoplasias de la Próstata / Benzamidas / Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas B-raf / Antineoplásicos / Nitrilos Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos