Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application.

Parakasikron, Nattihda; Chaotham, Chatchai; Chanvorachote, Pithi; Vinayanuwattikun, Chanida; Buranasudja, Visarut; Taweecheep, Pornchanok; Khantasup, Kannika

Parakasikron, Nattihda; Chaotham, Chatchai; Chanvorachote, Pithi; Vinayanuwattikun, Chanida; Buranasudja, Visarut; Taweecheep, Pornchanok; Khantasup, Kannika.

Afiliación

Parakasikron N; The Medical Microbiology Program, Graduate School, Chulalongkorn University, Bangkok, Thailand.
Chaotham C; Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Chanvorachote P; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Vinayanuwattikun C; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Buranasudja V; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Taweecheep P; Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Khantasup K; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

Drug Deliv ; 28(1): 1443-1454, 2021 Dec.

Article en En | MEDLINE | ID: mdl-34236266

Asunto(s)

Bacteriófagos/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Receptor 1 de Folato/antagonistas & inhibidores; Fragmentos de Inmunoglobulinas/farmacología; Neoplasias Pulmonares/tratamiento farmacológico; Línea Celular Tumoral; Humanos; Fragmentos de Inmunoglobulinas/administración & dosificación; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Non-small-cell lung cancer (NSCLC); alpha folate receptor (FRα); phage display; targeted therapy; variable domain of a heavy-chain (VH)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bacteriófagos / Fragmentos de Inmunoglobulinas / Carcinoma de Pulmón de Células no Pequeñas / Receptor 1 de Folato / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2021 Tipo del documento: Article País de afiliación: Tailandia

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