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Bis(ethylmaltolato)oxidovanadium (IV) alleviates neuronal apoptosis through regulating peroxisome proliferator-activated receptor γ in a triple transgenic animal model of Alzheimer's disease.
He, Zhijun; Song, Jianxi; Li, Xuexia; Li, Xiaoqian; Zhu, Huazhang; Wu, Chong; Xiao, Wen; Du, Xiubo; Ni, Jiazuan; Li, Nan; Liu, Qiong.
Afiliación
  • He Z; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
  • Song J; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
  • Li X; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
  • Li X; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
  • Zhu H; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
  • Wu C; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
  • Xiao W; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
  • Du X; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
  • Ni J; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
  • Li N; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
  • Liu Q; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518055, Guangdong, China.
J Biol Inorg Chem ; 26(5): 551-568, 2021 08.
Article en En | MEDLINE | ID: mdl-34240269
Endoplasmic reticulum stress (ER stress) plays a critical role in neuronal apoptosis along with the aggravation of Alzheimer's disease (AD). Nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that is involved in regulating ER stress in Alzheimer's disease (AD), therefore, this protein could be a promising therapeutic target for AD. Vanadium compounds, such as vanadyl acetylacetonate, sodium metavanadate and bis(maltolato)oxovanadium, are well-known as puissant PPARγ modulators. Thus, we are curious whether bis(ethylmaltolato)oxidovanadium (IV) (BEOV) can ameliorate ER stress and subsequent neuronal apoptosis by regulating PPARγ in AD models. To this end, we determined the effect of BEOV on behavioral performance, ER stress and neuronal apoptosis in the triple transgenic mouse AD model (3×Tg-AD). Our results showed that BEOV improved cognitive abilities and reduced the ER stress- and apoptosis-associated proteins in the brains of 3×Tg-AD mice. In vitro administration of BEOV in primary hippocampal neurons and N2asw cells achieved similar results in repressing ER stress. In addition, cotreatment with GW9662 (an antagonist of PPARγ) effectively blocked these neuroprotective effects of BEOV, which provided strong evidence that PPARγ-dependent signaling plays a key role in protecting against ER stress and neuronal apoptosis in AD. In conclusion, our data demonstrated that BEOV alleviated neuronal apoptosis triggered by ER stress by regulating PPARγ in a 3×Tg-AD model.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Apoptosis / Fármacos Neuroprotectores / PPAR gamma / Modelos Animales de Enfermedad / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biol Inorg Chem Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Apoptosis / Fármacos Neuroprotectores / PPAR gamma / Modelos Animales de Enfermedad / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biol Inorg Chem Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China