Ivermectin: A Promising Therapeutic for Fighting Malaria. Current Status and Perspective.
J Med Chem
; 64(14): 9711-9731, 2021 07 22.
Article
en En
| MEDLINE
| ID: mdl-34242031
ABSTRACT
Finding new chemotherapeutic interventions to treat malaria through repurposing of time-tested drugs and rigorous design of new drugs using tools of rational drug design remains one of the most sought strategies at the disposal of medicinal chemists. Ivermectin, a semisynthetic derivative of avermectin B1, is among the efficacious drugs used in mass drug administration drives employed against onchocerciasis, lymphatic filariasis, and several other parasitic diseases in humans. In this review, we present the prowess of ivermectin, a potent endectocide, in the control of malaria through vector control to reduce parasite transmission combined with efficacious chemoprevention to reduce malaria-related fatalities.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Malaria
/
Antimaláricos
Límite:
Humans
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
India