Visibility-graphlet approach to the output series of a Hodgkin-Huxley neuron.

ABSTRACT

The output signals of neurons that are exposed to external stimuli are of great importance for brain functionality. Traditional time-series analysis methods have provided encouraging results; however, the associated patterns and their correlations in the output signals of neurons are masked by statistical procedures. Here, graphlets are employed to extract the local temporal patterns and the transitions between them from the output signals when neurons are exposed to external stimuli with selected stimulating periods. A transition network is defined where the node is the graphlet and the direct link is the transition between two successive graphlets. The transition-network structure is affected by the simulating periods. When the stimulating period moves close to an integer multiple of the neuronal intrinsic period, only the backbone or core survives, while the other linkages disappear. Interestingly, the size of the backbone (number of nodes) equals the multiple. The transition-network structure is conservative within each stimulating region, which is defined as the range between two successive integer multiples. Nevertheless, the backbone or detailed structure is significantly altered between different stimulating regions. This alternation is induced primarily from a total of 12 active linkages. Hence, the transition network shows the structure of cross correlations in the output time-series for a single neuron.