Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis.

Bernardo-Faura, Marti; Rinas, Melanie; Wirbel, Jakob; Pertsovskaya, Inna; Pliaka, Vicky; Messinis, Dimitris E; Vila, Gemma; Sakellaropoulos, Theodore; Faigle, Wolfgang; Stridh, Pernilla; Behrens, Janina R; Olsson, Tomas; Martin, Roland; Paul, Friedemann; Alexopoulos, Leonidas G; Villoslada, Pablo; Saez-Rodriguez, Julio

Bernardo-Faura, Marti; Rinas, Melanie; Wirbel, Jakob; Pertsovskaya, Inna; Pliaka, Vicky; Messinis, Dimitris E; Vila, Gemma; Sakellaropoulos, Theodore; Faigle, Wolfgang; Stridh, Pernilla; Behrens, Janina R; Olsson, Tomas; Martin, Roland; Paul, Friedemann; Alexopoulos, Leonidas G; Villoslada, Pablo; Saez-Rodriguez, Julio.

Afiliación

Bernardo-Faura M; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.
Rinas M; Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus UAB, Bellaterra, Barcelona, Spain.
Wirbel J; Joint Research Center for Computational Biomedicine (JRC-COMBINE), Faculty of Medicine, RWTH-Aachen University, Aachen, Germany.
Pertsovskaya I; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.
Pliaka V; Joint Research Center for Computational Biomedicine (JRC-COMBINE), Faculty of Medicine, RWTH-Aachen University, Aachen, Germany.
Messinis DE; Institut d' Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
Vila G; School of Mechanical Engineering, National Technical University of Athens, Zografou, Greece.
Sakellaropoulos T; ProtATonce Ltd., Athens, Greece.
Faigle W; Institut d' Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
Stridh P; School of Mechanical Engineering, National Technical University of Athens, Zografou, Greece.
Behrens JR; University of Zurich, Zurich, Switzerland.
Olsson T; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Martin R; NeuroCure Clinical Research Center and Department of Neurology, Charité University Medicine Berlin, Berlin, Germany.
Paul F; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Alexopoulos LG; University of Zurich, Zurich, Switzerland.
Villoslada P; NeuroCure Clinical Research Center and Department of Neurology, Charité University Medicine Berlin, Berlin, Germany.
Saez-Rodriguez J; School of Mechanical Engineering, National Technical University of Athens, Zografou, Greece. leo@mail.ntua.gr.

Genome Med ; 13(1): 117, 2021 07 16.

Article en En | MEDLINE | ID: mdl-34271980

Asunto(s)

Sistema Inmunológico/metabolismo; Modelos Biológicos; Esclerosis Múltiple/metabolismo; Esclerosis Múltiple/terapia; Transducción de Señal; Adulto; Algoritmos; Biomarcadores; Estudios de Casos y Controles; Terapia Combinada/métodos; Manejo de la Enfermedad; Susceptibilidad a Enfermedades; Femenino; Humanos; Sistema Inmunológico/efectos de los fármacos; Sistema Inmunológico/inmunología; Masculino; Persona de Mediana Edad; Terapia Molecular Dirigida; Esclerosis Múltiple/diagnóstico; Esclerosis Múltiple/etiología; Fosfoproteínas/metabolismo; Pronóstico; Proteoma; Proteómica/métodos; Transducción de Señal/efectos de los fármacos; Resultado del Tratamiento

Palabras clave

Combination therapy; Immunotherapy; Kinases; Logic modeling; Multiple sclerosis; Network modeling; Pathways; Personalized medicine; Phosphoproteomics; Signaling networks; Treatment; xMAP assay

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transducción de Señal / Sistema Inmunológico / Modelos Biológicos / Esclerosis Múltiple Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Genome Med Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

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