Novel insights on the molecular mechanism of action of the anti-angiogenic pyrazolyl-urea GeGe-3 by functional proteomics.

Morretta, Elva; Belvedere, Raffaella; Petrella, Antonello; Spallarossa, Andrea; Rapetti, Federica; Bruno, Olga; Brullo, Chiara; Monti, Maria Chiara

Morretta, Elva; Belvedere, Raffaella; Petrella, Antonello; Spallarossa, Andrea; Rapetti, Federica; Bruno, Olga; Brullo, Chiara; Monti, Maria Chiara.

Afiliación

Morretta E; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy. Electronic address: emorretta@unisa.it.
Belvedere R; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy. Electronic address: rbelvedere@unisa.it.
Petrella A; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy. Electronic address: apetrella@unisa.it.
Spallarossa A; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy. Electronic address: andrea.spallarossa@unige.it.
Rapetti F; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy. Electronic address: federica.rapetti@edu.unige.it.
Bruno O; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy. Electronic address: obruno@unige.it.
Brullo C; Department of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy. Electronic address: brullo@difar.unige.it.
Monti MC; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy. Electronic address: mcmonti@unisa.it.

Bioorg Chem ; 115: 105168, 2021 10.

Article en En | MEDLINE | ID: mdl-34284173

Asunto(s)

Inhibidores de la Angiogénesis/química; Proteoma/metabolismo; Proteómica/métodos; Pirazoles/química; Urea/química; Inhibidores de la Angiogénesis/metabolismo; Inhibidores de la Angiogénesis/farmacología; Sitios de Unión; Calcio/metabolismo; Calreticulina/química; Calreticulina/metabolismo; Regulación hacia Abajo/efectos de los fármacos; Quinasa 1 de Adhesión Focal/metabolismo; Células Endoteliales de la Vena Umbilical Humana; Humanos; Ionomicina/farmacología; Simulación del Acoplamiento Molecular; Proteoma/efectos de los fármacos

Palabras clave

Angiogenesis; Calcium homeostasis; Drug affinity responsive target stability; Functional proteomics; Limited proteolysis; Molecular docking; Proteinligand interactions; Target discovery

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirazoles / Urea / Inhibidores de la Angiogénesis / Proteoma / Proteómica Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article

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