Association of Soy and Exclusive Breastfeeding With Central Precocious Puberty: A Case-Control Study.
Front Endocrinol (Lausanne)
; 12: 667029, 2021.
Article
en En
| MEDLINE
| ID: mdl-34290667
ABSTRACT
Introduction:
While soy is suggested as a possible risk factor, exclusive breastfeeding (EBF) has a likely protective effect in precocious puberty. Our aim was to evaluate the association between both of these variables with central precocious puberty (CPP).Methods:
We performed a retrospective, case-control study. A total of 161 girls were divided into two groups 84 patients diagnosed with CPP composed the case group and 77 patients without the diagnosis of CPP (had gone through normal onset of puberty) were the control group.Results:
Our control group had a higher presence of EBF >6 months, which was an important protective factor for CPP (OR 0.5; IC 95% 0.3-0.9, p = 0.05) and also correlated negatively with the presence of it (r = -0.2; p < 0.05). Oppositely, the use of soy was significantly higher in the CPP group, (OR 3.8; IC 95% 1.5-6, p < 0.05) and positively correlating (r = 0.2; p < 0.01) with the presence of CPP. Duration of soy intake (years) correlated with bone age (r = 0.415; p < 0.05). A logistic regression was performed to evaluate the effects of EBF duration and soy on CPP. The model was significant (x² (2) = 20,715, p = <0.001) and explained 12.2% (Nagelkerke R2) of the variance, correctly classifying 62.5% of cases. EBF was associated with a reduction of likelihood of having CPP [OR = 0,187 (CI = 0.055-0,635); Wald = 7,222, p = 0.007], while soy intake increased the risk [OR = 3.505 (CI) = 1,688-7,279, Wald = 11,319, p = 0.001].Conclusion:
Our data found the use of soy was associated with CPP. Additionally, EBF was pointed as a protective factor. However, future prospective studies are needed to clarify this issue.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pubertad Precoz
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Glycine max
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Lactancia Materna
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Factores Protectores
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child
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Female
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Humans
Idioma:
En
Revista:
Front Endocrinol (Lausanne)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil