A Novel Attenuated Enterovirus A71 Mutant with VP1-V238A,K244R Exhibits Reduced Efficiency of Cell Entry/Exit and Augmented Binding Affinity to Sulfated Glycans.

Meng, Tao; Wong, Sek-Man; Chua, Kaw-Bing

Meng, Tao; Wong, Sek-Man; Chua, Kaw-Bing.

Afiliación

Meng T; Temasek Life Sciences Laboratorygrid.226688.0, Limited, Republic of Singapore.
Wong SM; Department of Biological Sciences, National University of Singaporegrid.4280.e, Republic of Singapore.
Chua KB; Temasek Life Sciences Laboratorygrid.226688.0, Limited, Republic of Singapore.

J Virol ; 95(22): e0105521, 2021 10 27.

Article en En | MEDLINE | ID: mdl-34468173

Asunto(s)

Enterovirus Humano A; Enfermedad de Boca, Mano y Pie/virología; Animales; Anticuerpos Neutralizantes; Antígenos Virales; Línea Celular Tumoral; Chlorocebus aethiops; Enterovirus Humano A/patogenicidad; Enterovirus Humano A/fisiología; Humanos; Ratones; Células 3T3 NIH; Células Vero; Virulencia; Internalización del Virus; Replicación Viral

Palabras clave

cell-adapted mutants; enterovirus A71; live attenuated vaccines; sulfated glycans; virulence determinants; virus dissemination; virus entry/exit

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enterovirus Humano A / Enfermedad de Boca, Mano y Pie Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Virol Año: 2021 Tipo del documento: Article

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