Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1&#945; inhibitor for cancer therapy.

Li, Guangzhe; Shao, Yujie; Pan, Yue; Li, Yueqing; Wang, Yang; Wang, Liu; Wang, Xu; Shao, Kun; Wang, Shisheng; Liu, Naixuan; Zhang, Jingdong; Zhao, Weijie; Nakamura, Hiroyuki

Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy.

Li, Guangzhe; Shao, Yujie; Pan, Yue; Li, Yueqing; Wang, Yang; Wang, Liu; Wang, Xu; Shao, Kun; Wang, Shisheng; Liu, Naixuan; Zhang, Jingdong; Zhao, Weijie; Nakamura, Hiroyuki.

Afiliación

Li G; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China. Electronic address: liguangzhe@dlut.edu.cn.
Shao Y; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Pan Y; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Li Y; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Wang Y; State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Wang L; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Wang X; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Shao K; State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Wang S; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Liu N; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Zhang J; Medical Oncology Department of Gastrointestinal Cancer, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, Shenyang 110042, China.
Zhao W; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Nakamura H; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan.

Bioorg Med Chem Lett ; 50: 128338, 2021 10 15.

Article en En | MEDLINE | ID: mdl-34469710

Asunto(s)

Antineoplásicos/farmacología; Productos Biológicos/farmacología; Subunidad alfa del Factor 1 Inducible por Hipoxia/antagonistas & inhibidores; Animales; Antineoplásicos/síntesis química; Antineoplásicos/química; Productos Biológicos/síntesis química; Productos Biológicos/química; Línea Celular Tumoral; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Poríferos; Factor A de Crecimiento Endotelial Vascular/genética; Factor A de Crecimiento Endotelial Vascular/metabolismo

Palabras clave

7-Hydroxyneolamellarin A; Anti-tumor; HIF-1α inhibition; Total synthesis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Productos Biológicos / Subunidad alfa del Factor 1 Inducible por Hipoxia / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article

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