Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker.
Clin Cardiol
; 44(11): 1586-1593, 2021 Nov.
Article
en En
| MEDLINE
| ID: mdl-34528718
ABSTRACT
BACKGROUND:
Coronary microvascular dysfunction (CMD) is associated with heart failure with preserved ejection fraction (HFpEF); however, pathophysiology is not well described.HYPOTHESIS:
We hypothesized that CMD in women with suspected ischemia with no obstructive coronary artery disease (INOCA) is associated with cardiomyocyte dysfunction reflected by plasma levels of a cardiomyocyte calcium handling protein, cardiac bridge integrator 1 (cBIN1).METHODS:
Women with suspected INOCA undergoing coronary function testing were included. Coronary flow reserve, vasodilation to nitroglycerin, change in coronary blood flow (ΔCBF), and vasodilation to acetylcholine (ΔAch) were evaluated. cBIN1 score (CS) levels in these women (n = 39) were compared to women with HFpEF (n = 20), heart failure with reduced ejection fraction (HFrEF) (n = 36), and reference controls (RC) (n = 50). Higher CS indicates cardiomyocyte tubule dysfunction.RESULTS:
INOCA, HFpEF, and HFrEF women were older than RC (p < .05). Higher CS was associated with vasoconstriction to acetylcholine (r = -0.43, p = .011) with a trend towards lower ΔCBF (r = 0.30, p = .086). Higher CS was specific for ΔAch and ΔCBF but had limited sensitivity. INOCA women had higher CS than RC, but lower CS than HFpEF/HFrEF groups (p < .001).CONCLUSIONS:
CS, a plasma biomarker indicating poor cardiomyocyte health, was higher in women with suspected INOCA as compared to RC, but lower than in women with HFpEF. Elevated CS in suspected INOCA patients represents an intermediate group between health and disease, supporting the hypothesis that CMD may progress to HFpEF. Larger prospective cohort studies are needed to confirm the pathophysiological relationship between cBIN1, CMD, and HFpEF.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Proteínas Supresoras de Tumor
/
Proteínas Adaptadoras Transductoras de Señales
/
Insuficiencia Cardíaca
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
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Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Clin Cardiol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá