Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial.
Aging Clin Exp Res
; 34(3): 515-525, 2022 Mar.
Article
en En
| MEDLINE
| ID: mdl-34533774
ABSTRACT
BACKGROUND:
The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults.AIMS:
To assess whether iron deficiency at baseline and at any yearly follow-up time point, with or without anemia, was associated with changes from baseline in high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels over 3 years.METHODS:
This is a post-hoc observational analysis of DO-HEALTH, a double-blind, randomized controlled trial including 2157 European community-dwelling adults age 70+. The outcomes were changes from baseline in hs-CRP and IL-6 levels, measured at 12, 24, and 36 months of follow-up. Iron deficiency was defined by soluble transferrin receptor levels > 28.1 nmol/L and baseline anemia by hemoglobin levels < 130 g/L for men and < 120 g/L for women.RESULTS:
In total, 2141 participants were included in the analyses (mean age 74.9 years, 61.5% of women, 26.8% with iron deficiency). Baseline iron deficiency was associated with greater increase in IL-6 levels (mean difference in change 0.52 ng/L, 95%CI 0.03-1.00, P = .04) over 3 years. Iron deficiency at any yearly time point was associated with higher increases in hs-CRP (mean difference in change 1.62 mg/L, 95%CI 0.98-2.26, P < .001) and IL-6 levels (mean difference in change 1.33 ng/L, 95%CI 0.87-1.79, P < .001) over 3 years. No significant interaction between iron deficiency and anemia was found, suggesting that the results are independent of the anemic status.CONCLUSIONS:
These findings suggest that iron deficiency may play a role in low-grade chronic inflammation among relatively healthy older adults.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Anemia Ferropénica
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Deficiencias de Hierro
Tipo de estudio:
Clinical_trials
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Observational_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Aging Clin Exp Res
Asunto de la revista:
GERIATRIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Suiza