Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in Woodchucks.

Korolowicz, Kyle E; Suresh, Manasa; Li, Bin; Huang, Xu; Yon, Changsuek; Kallakury, Bhaskar V; Lee, Kyoung-Pil; Park, Sungman; Kim, Yoon-Won; Menne, Stephan

Korolowicz, Kyle E; Suresh, Manasa; Li, Bin; Huang, Xu; Yon, Changsuek; Kallakury, Bhaskar V; Lee, Kyoung-Pil; Park, Sungman; Kim, Yoon-Won; Menne, Stephan.

Afiliación

Korolowicz KE; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.
Suresh M; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.
Li B; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.
Huang X; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.
Yon C; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.
Kallakury BV; Department of Pathology, Georgetown University Medical Center, Washington, DC 20057, USA.
Lee KP; ImmuneMed, Inc., Chuncheon BioTown, Soyanggang ro 32, Chuncheon-si 24232, Gangwon-do, Korea.
Park S; ImmuneMed, Inc., Chuncheon BioTown, Soyanggang ro 32, Chuncheon-si 24232, Gangwon-do, Korea.
Kim YW; ImmuneMed, Inc., Chuncheon BioTown, Soyanggang ro 32, Chuncheon-si 24232, Gangwon-do, Korea.
Menne S; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.

Cells ; 10(9)2021 09 05.

Article en En | MEDLINE | ID: mdl-34571970

Asunto(s)

Alanina/farmacología; Anticuerpos Monoclonales Humanizados/farmacología; Antivirales/farmacología; Virus de la Hepatitis B de la Marmota/efectos de los fármacos; Hepatitis B/tratamiento farmacológico; Hígado/efectos de los fármacos; Tenofovir/análogos & derivados; Vimentina/antagonistas & inhibidores; Internalización del Virus/efectos de los fármacos; Animales; Modelos Animales de Enfermedad; Quimioterapia Combinada; Endocitosis/efectos de los fármacos; Células Hep G2; Hepatitis B/metabolismo; Hepatitis B/virología; Virus de la Hepatitis B de la Marmota/patogenicidad; Interacciones Huésped-Patógeno; Humanos; Hígado/metabolismo; Hígado/virología; Marmota; Tenofovir/farmacología; Vimentina/metabolismo; Carga Viral; Replicación Viral/efectos de los fármacos

Palabras clave

antiviral efficacy; chronic hepatitis B; entry inhibitor; hepatitis B virus; humanized antibody; hzVSF; liver inflammation; safety; tenofovir alafenamide fumarate; vimentin; woodchuck

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Vimentina / Virus de la Hepatitis B de la Marmota / Alanina / Internalización del Virus / Anticuerpos Monoclonales Humanizados / Tenofovir / Hepatitis B / Hígado Límite: Animals / Humans Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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