Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities.
Nat Prod Res
; 37(3): 375-382, 2023 Feb.
Article
en En
| MEDLINE
| ID: mdl-34587845
ABSTRACT
A new triterpenoid saponin, 3-O-ß-D-allopyranosyl (1â3)-α-L-rhamnopyranosyl (1â2)-α-L-arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl (1â4)-ß-D-glucopyranosyl (1â6)-ß-D-glucopyranosyl ester (IV), together with six known ones Hederacholichiside F (I), Tanguticoside B (II), Tauroside St-H1 (III), Hederoside H1 (V), Kalopanaxsaponin G (VI), Hederasaponin B (VII) were separated from Clematis tangutica (Maxim.) Korsh. Their cytotoxic activities were evaluated. Saponins IV (new compound) and I showed selective inhibitory activities against HGC-27 with IC50 values of 20.17 and 66.18 µM. Saponin VII exhibited extensive inhibitory action against HGC-27, Hela and SK-OV-3 with IC50 values of 16.47-71.36 µM. Saponin III showed selective inhibitory activity against SK-OV-3 with the IC50 value of 48.70 µM. All isolated saponins were inactive (IC50 >150 µM) to GES-1.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Saponinas
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Triterpenos
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Clematis
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Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
China