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CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer.
Gao, Shanshan; Soares, Fraser; Wang, Shiyan; Wong, Chi Chun; Chen, Huarong; Yang, Zhenjie; Liu, Weixin; Go, Minnie Y Y; Ahmed, Musaddeque; Zeng, Yong; O'Brien, Catherine Adell; Sung, Joseph J Y; He, Housheng Hansen; Yu, Jun.
Afiliación
  • Gao S; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
  • Soares F; Princess Margaret Cancer Centre, University Health Network, Ontario, ON, Canada.
  • Wang S; Princess Margaret Cancer Centre, University Health Network, Ontario, ON, Canada.
  • Wong CC; Princess Margaret Cancer Centre, University Health Network, Ontario, ON, Canada.
  • Chen H; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
  • Yang Z; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
  • Liu W; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
  • Go MYY; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
  • Ahmed M; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
  • Zeng Y; Princess Margaret Cancer Centre, University Health Network, Ontario, ON, Canada.
  • O'Brien CA; Princess Margaret Cancer Centre, University Health Network, Ontario, ON, Canada.
  • Sung JJY; Princess Margaret Cancer Centre, University Health Network, Ontario, ON, Canada.
  • He HH; Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
  • Yu J; Princess Margaret Cancer Centre, University Health Network, Ontario, ON, Canada. hansenhe@uhnresearch.ca.
Oncogene ; 40(48): 6601-6613, 2021 12.
Article en En | MEDLINE | ID: mdl-34621019
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Protocolos de Quimioterapia Combinada Antineoplásica / Colesterol / Neoplasias del Colon / Resistencia a Antineoplásicos / Dimetilaliltranstransferasa / Farnesiltransferasa / Geraniltranstransferasa / Sistemas CRISPR-Cas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Protocolos de Quimioterapia Combinada Antineoplásica / Colesterol / Neoplasias del Colon / Resistencia a Antineoplásicos / Dimetilaliltranstransferasa / Farnesiltransferasa / Geraniltranstransferasa / Sistemas CRISPR-Cas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: China