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Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.
Kopczynski, Michal; Rumienczyk, Izabela; Kulecka, Maria; Statkiewicz, Malgorzata; Pysniak, Kazimiera; Sandowska-Markiewicz, Zuzanna; Wojcik-Trechcinska, Urszula; Goryca, Krzysztof; Pyziak, Karolina; Majewska, Eliza; Masiejczyk, Magdalena; Wojcik-Jaszczynska, Katarzyna; Rzymski, Tomasz; Bomsztyk, Karol; Ostrowski, Jerzy; Mikula, Michal.
Afiliación
  • Kopczynski M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
  • Rumienczyk I; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
  • Kulecka M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
  • Statkiewicz M; Department of Gastroenterology, Hepatology and Clinical Oncology, Centre for Postgraduate Medical Education, 01-813 Warsaw, Poland.
  • Pysniak K; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
  • Sandowska-Markiewicz Z; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
  • Wojcik-Trechcinska U; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
  • Goryca K; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
  • Pyziak K; Genomics Core Facility, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.
  • Majewska E; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland.
  • Masiejczyk M; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland.
  • Wojcik-Jaszczynska K; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland.
  • Rzymski T; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland.
  • Bomsztyk K; Biology R&D, Ryvu Therapeutics S.A., 30-394 Krakow, Poland.
  • Ostrowski J; UW Medicine South Lake Union, University of Washington, Seattle, WA 98109, USA.
  • Mikula M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Int J Mol Sci ; 22(19)2021 Sep 22.
Article en En | MEDLINE | ID: mdl-34638546
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piperazinas / Piridinas / Pirrolidinas / Triazoles / Factor de Necrosis Tumoral alfa / Endotoxemia / Proteína Quinasa 3 Activada por Mitógenos / Indazoles / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Polonia
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piperazinas / Piridinas / Pirrolidinas / Triazoles / Factor de Necrosis Tumoral alfa / Endotoxemia / Proteína Quinasa 3 Activada por Mitógenos / Indazoles / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Polonia