Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-&#954;B signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo.

Yang, Song; Li, Fangyu; Lu, Shuyan; Ren, Limei; Bian, Shuai; Liu, Meichen; Zhao, Daqing; Wang, Siming; Wang, Jiawen

Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo.

Yang, Song; Li, Fangyu; Lu, Shuyan; Ren, Limei; Bian, Shuai; Liu, Meichen; Zhao, Daqing; Wang, Siming; Wang, Jiawen.

Afiliación

Yang S; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: 1244161293@qq.com.
Li F; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: L18843926718@163.com.
Lu S; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: lushuyan1996@163.com.
Ren L; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: 1687416854@qq.com.
Bian S; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: 18843449574@163.com.
Liu M; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: liumc0367@163.com.
Zhao D; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: zhaodaqing1963@163.com.
Wang S; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: lwsm126030@126.com.
Wang J; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address: wangjiawen1229@163.com.

J Ethnopharmacol ; 283: 114739, 2022 Jan 30.

Article en En | MEDLINE | ID: mdl-34648903

Asunto(s)

Antiinflamatorios/farmacología; Estrés Oxidativo/efectos de los fármacos; Panax/química; Extractos Vegetales/farmacología; Animales; Antiinflamatorios/aislamiento & purificación; Autofagia/efectos de los fármacos; Sulfato de Dextran; Modelos Animales de Enfermedad; Técnicas de Silenciamiento del Gen; Inflamación/tratamiento farmacológico; Proteína 1 Asociada A ECH Tipo Kelch/metabolismo; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Masculino; Ratones; Ratones Endogámicos C57BL; Factor 2 Relacionado con NF-E2/metabolismo; FN-kappa B/metabolismo; Células RAW 264.7; Transducción de Señal/efectos de los fármacos

Palabras clave

Autophagy; Ginseng root extract; Inflammation; MAPK/NF-κB; Oxidative damage; p62-Nrf2-Keap1

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Extractos Vegetales / Estrés Oxidativo / Panax / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Ethnopharmacol Año: 2022 Tipo del documento: Article

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