Increased Prevalence of Beta-Cell Dysfunction despite Normal HbA1c in Youth and Young Adults with Turner Syndrome.
Horm Res Paediatr
; 94(7-8): 297-306, 2021.
Article
en En
| MEDLINE
| ID: mdl-34657042
ABSTRACT
INTRODUCTION:
Adult women with Turner syndrome (TS) have a high prevalence of diabetes and ß-cell dysfunction that increases morbidity and mortality, but it is unknown if there is ß-cell dysfunction present in youth with TS. This study aimed to determine the prevalence of ß-cell dysfunction in youth with TS and the impact of traditional therapies on insulin sensitivity (SI) and insulin secretion.METHODS:
Cross-sectional, observational study recruited 60 girls with TS and 60 healthy controls (HC) matched on pubertal status. Each subject had a history, physical exam, and oral glucose tolerance test (OGTT). Oral glucose and c-peptide minimal modeling was used to determine ß-cell function.RESULTS:
Twenty-one TS girls (35%) met criteria for prediabetes. Impaired fasting glucose was present in 18% of girls with TS and 3% HC (p value = 0.02). Impaired glucose tolerance was present in 23% of TS girls and 0% HC (p value <0.001). The hemoglobin A1c was not different between TS and HC (median 5%, p = 0.42). Youth with TS had significant reductions in SI, ß-cell responsivity (Φ), and disposition index (DI) compared to HC. These differences remained significant when controlling for body mass index z-score (p values 0.0006, 0.002, <0.0001 for SI, Φ total, DI, respectively).CONCLUSIONS:
ß-Cell dysfunction is present in youth with TS compared to controls. The presence of both reduced insulin secretion and SI suggest a unique TS-related glycemic phenotype. Based on the data from this study, we strongly suggest that providers employ serial OGTT to screen for glucose abnormalities in TS youth.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Síndrome de Turner
/
Glucemia
/
Péptido C
/
Hemoglobina Glucada
/
Diabetes Mellitus
/
Prueba de Tolerancia a la Glucosa
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Horm Res Paediatr
Asunto de la revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos