The opioid antagonist naltrexone decreases seizure-like activity in genetic and chemically induced epilepsy models.

Sturgeon, Morgan L; Langton, Rachel; Sharma, Shaunik; Cornell, Robert A; Glykys, Joseph; Bassuk, Alexander G

Sturgeon, Morgan L; Langton, Rachel; Sharma, Shaunik; Cornell, Robert A; Glykys, Joseph; Bassuk, Alexander G.

Afiliación

Sturgeon ML; Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, USA.
Langton R; Department of Pediatrics, Division of Child Neurology, University of Iowa, Iowa City, IA, USA.
Sharma S; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
Cornell RA; Department of Neurology, University of Iowa, Iowa City, IA, USA.
Glykys J; Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, USA.
Bassuk AG; Department of Pediatrics, Division of Child Neurology, University of Iowa, Iowa City, IA, USA.

Epilepsia Open ; 6(3): 528-538, 2021 09.

Article en En | MEDLINE | ID: mdl-34664432

Asunto(s)

Epilepsia; Naltrexona; Animales; Humanos; Ratones; Naltrexona/efectos adversos; Antagonistas de Narcóticos/efectos adversos; Convulsiones/inducido químicamente; Convulsiones/tratamiento farmacológico; Convulsiones/genética; Pez Cebra

Palabras clave

scn1Lab; Zebrafish; drug repurpose; mice; naltrexone; pentylenetetrazole

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Epilepsia / Naltrexona Límite: Animals / Humans Idioma: En Revista: Epilepsia Open Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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