Systemic biodistribution and hepatocyte-specific gene editing with CRISPR/Cas9 using hyaluronic acid-based nanoparticles.

Francis, Christopher; Wroblewska, Liliana; Pegman, Pamela; Amiji, Mansoor

Francis, Christopher; Wroblewska, Liliana; Pegman, Pamela; Amiji, Mansoor.

Afiliación

Francis C; Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, United States; Pfizer, Inc, Worldwide Research & Development, Medicinal Sciences, Biomedicine Design, Andover, MA, United States.
Wroblewska L; Pfizer, Inc, Worldwide Research & Development, Medicinal Sciences, Biomedicine Design, Cambridge, MA, United States.
Pegman P; Pfizer, Inc, Worldwide Research & Development, Medicinal Sciences, Bioprocess R&D, Andover, MA, United States.
Amiji M; Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, United States. Electronic address: m.amiji@northeastern.edu.

Nanomedicine ; 40: 102488, 2022 02.

Article en En | MEDLINE | ID: mdl-34748964

Asunto(s)

Edición Génica; Nanopartículas; Animales; Sistemas CRISPR-Cas/genética; Edición Génica/métodos; Hepatocitos; Ácido Hialurónico; Ratones; Distribución Tisular

Palabras clave

Biodistribution; CRISPR/Cas9 gene editing; Hepatocyte targeting; Hyaluronic acid nanoparticles; Rosa26

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Nanopartículas / Edición Génica Límite: Animals Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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