Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells.
Diabetes
; 71(2): 321-328, 2022 02 01.
Article
en En
| MEDLINE
| ID: mdl-34753798
ABSTRACT
Adipose-derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remodeling. Perivascular ADSCs (PV-ADSCs) draw attention because of their unique location. The heterogeneity of subcutaneous (SUB) and abdominal ADSCs were well addressed, but PV-ADSCs' heterogeneity has not been investigated. In this study, we applied single-cell analysis to compare SUB-ADSCs and PV-ADSCs regarding their subpopulations, functions, and cell fates. We uncovered four subpopulations of PV-ADSCs (Dpp4+, Col4a2+/Icam1+, Clec11a+/Cpe+, and Sult1e1+ cells), among which the Clec11a+ subpopulation potentially participated in and regulated PV-ADSC differentiation toward a smooth muscle cell (SMC) phenotype. Distinct characteristics between PV-ADSCs and SUB-ADSCs were revealed.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células Madre
/
Vasos Sanguíneos
/
Grasa Subcutánea
Límite:
Animals
Idioma:
En
Revista:
Diabetes
Año:
2022
Tipo del documento:
Article