Reduced urinary angiotensinogen excretion in preeclampsia.
Pregnancy Hypertens
; 27: 1-5, 2022 Mar.
Article
en En
| MEDLINE
| ID: mdl-34798372
ABSTRACT
OBJECTIVE:
This study evaluated urinary angiotensinogen in preeclampsia.METHODS:
Normal pregnant (n = 57) and preeclamptic patients (n = 31); Normal pregnant (n = 10) and preeclamptic rats (n = 10) were studied. Urinary angiotensinogen and plasma angiotensin II were assayed by enzyme-linked immunosorbent assay (ELISA).RESULTS:
Urinary angiotensinogen in preeclampsia patients (2.0 ± 1.1 ng/mg creatinine) was suppressed (*p < 0.05) compared to normal pregnant (2.7 ± 1.5 ng/mg creatinine). Plasma angiotensin II in preeclampsia patients (preeclampsia 36.2 ± 7; normal pregnant 48.1 ± 5 fmol/mL) was lower. The similar result was observed in preeclampsia rat model.CONCLUSIONS:
The reduced urinary excretion of angiotensinogen was both in human preeclampsia patients and rat model of preeclampsia.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Angiotensinógeno
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Pregnancy Hypertens
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos