Cellular and molecular mechanisms regulating the KNDy neuronal activities to generate and modulate GnRH pulse in mammals.
Front Neuroendocrinol
; 64: 100968, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34808231
ABSTRACT
Accumulating findings during the past decades have demonstrated that the hypothalamic arcuate kisspeptin neurons are supposed to be responsible for pulsatile release of gonadotropin-releasing hormone (GnRH) to regulate gametogenesis and steroidogenesis in mammals. The arcuate kisspeptin neurons express neurokinin B (NKB) and dynorphin A (Dyn), thus, the neurons are also referred to as KNDy neurons. In the present article, we mainly focus on the cellular and molecular mechanisms underlying GnRH pulse generation, that is focused on the action of NKB and Dyn and an interaction between KNDy neurons and astrocytes to control GnRH pulse generation. Then, we also discuss the factors that modulate the activity of KNDy neurons and consequent pulsatile GnRH/LH release in mammals.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Núcleo Arqueado del Hipotálamo
/
Hormona Liberadora de Gonadotropina
Límite:
Animals
Idioma:
En
Revista:
Front Neuroendocrinol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón