Early upregulation of cytosolic phospholipase A<sub>2</sub>&#945; in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis.

Malada Edelstein, Yafa Fetfet; Solomonov, Yulia; Hadad, Nurit; Alfahel, Leenor; Israelson, Adrian; Levy, Rachel

Early upregulation of cytosolic phospholipase A₂α in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis.

Malada Edelstein, Yafa Fetfet; Solomonov, Yulia; Hadad, Nurit; Alfahel, Leenor; Israelson, Adrian; Levy, Rachel.

Afiliación

Malada Edelstein YF; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, 84105, Beer Sheva, Israel.
Solomonov Y; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, 84105, Beer Sheva, Israel.
Hadad N; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, 84105, Beer Sheva, Israel.
Alfahel L; Department of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Israelson A; Department of Physiology and Cell Biology, Faculty of Health Sciences and The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Levy R; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, 84105, Beer Sheva, Israel. ral@bgu.ac.il.

J Neuroinflammation ; 18(1): 274, 2021 Nov 25.

Article en En | MEDLINE | ID: mdl-34823547

Asunto(s)

Esclerosis Amiotrófica Lateral/metabolismo; Fosfolipasas A2 Grupo IV/metabolismo; Neuronas Motoras/metabolismo; Superóxido Dismutasa-1/metabolismo; Regulación hacia Arriba; Animales; Modelos Animales de Enfermedad; Ratones; Pliegue de Proteína; Médula Espinal/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

ALS; Cytosolic phospholipase A2α; Misfolded SOD1; Motor neurons; Mutant SOD1G93A; TNFα

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Regulación hacia Arriba / Fosfolipasas A2 Grupo IV / Superóxido Dismutasa-1 / Esclerosis Amiotrófica Lateral / Neuronas Motoras Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neuroinflammation Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Israel

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google