ProteoDisco: a flexible R approach to generate customized protein databases for extended search space of novel and variant proteins in proteogenomic studies.
Bioinformatics
; 38(5): 1437-1439, 2022 02 07.
Article
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| MEDLINE
| ID: mdl-34864882
ABSTRACT
SUMMARY:
We present an R-based open-source software termed ProteoDisco that allows for flexible incorporation of genomic variants, fusion genes and (aberrant) transcriptomic variants from standardized formats into protein variant sequences. ProteoDisco allows for a flexible step-by-step workflow allowing for in-depth customization to suit a myriad of research approaches in the field of proteogenomics, on all organisms for which a reference genome and transcript annotations are available. AVAILABILITY AND IMPLEMENTATION ProteoDisco (R package version ≥ 1.0.0) is available on Bioconductor at https//doi.org/doi10.18129/B9.bioc.ProteoDisco and from https//github.com/ErasmusMC-CCBC/ProteoDisco/. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteogenómica
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Países Bajos