1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and <i>in silico</i> studies.

Hagras, Mohamed; Saleh, Marwa A; Ezz Eldin, Rogy R; Abuelkhir, Abdelrahman A; Khidr, Emad Gamil; El-Husseiny, Ahmed A; El-Mahdy, Hesham A; Elkaeed, Eslam B; Eissa, Ibrahim H

1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies.

Hagras, Mohamed; Saleh, Marwa A; Ezz Eldin, Rogy R; Abuelkhir, Abdelrahman A; Khidr, Emad Gamil; El-Husseiny, Ahmed A; El-Mahdy, Hesham A; Elkaeed, Eslam B; Eissa, Ibrahim H.

Afiliación

Hagras M; Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Saleh MA; Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Ezz Eldin RR; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
Abuelkhir AA; Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Khidr EG; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
El-Husseiny AA; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
El-Mahdy HA; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.

J Enzyme Inhib Med Chem ; 37(1): 380-396, 2022 Dec.

Article en En | MEDLINE | ID: mdl-34923885

Asunto(s)

Antineoplásicos/farmacología; Diseño de Fármacos; Naftalenos/farmacología; Oxadiazoles/farmacología; Inhibidores de Proteínas Quinasas/farmacología; Receptor 2 de Factores de Crecimiento Endotelial Vascular/antagonistas & inhibidores; Antineoplásicos/síntesis química; Antineoplásicos/química; Apoptosis/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Células Cultivadas; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Simulación del Acoplamiento Molecular; Estructura Molecular; Naftalenos/síntesis química; Naftalenos/química; Oxadiazoles/síntesis química; Oxadiazoles/química; Inhibidores de Proteínas Quinasas/síntesis química; Inhibidores de Proteínas Quinasas/química; Relación Estructura-Actividad; Receptor 2 de Factores de Crecimiento Endotelial Vascular/metabolismo

Palabras clave

1,3,4-oxadiazole; Anticancer; VEGFR-2 inhibitors; apoptosis; docking

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxadiazoles / Diseño de Fármacos / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Inhibidores de Proteínas Quinasas / Naftalenos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Egipto

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