Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection.
Nat Immunol
; 23(1): 40-49, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34937928
ABSTRACT
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3-11 years) and adults. Antibody responses against spike protein were high in children and seroconversion boosted responses against seasonal Beta-coronaviruses through cross-recognition of the S2 domain. Neutralization of viral variants was comparable between children and adults. Spike-specific T cell responses were more than twice as high in children and were also detected in many seronegative children, indicating pre-existing cross-reactive responses to seasonal coronaviruses. Importantly, children retained antibody and cellular responses 6 months after infection, whereas relative waning occurred in adults. Spike-specific responses were also broadly stable beyond 12 months. Therefore, children generate robust, cross-reactive and sustained immune responses to SARS-CoV-2 with focused specificity for the spike protein. These findings provide insight into the relative clinical protection that occurs in most children and might help to guide the design of pediatric vaccination regimens.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Coronavirus Humano 229E
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Coronavirus Humano OC43
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Protección Cruzada
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Glicoproteína de la Espiga del Coronavirus
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SARS-CoV-2
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Anticuerpos Antivirales
Límite:
Adult
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Child
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Child, preschool
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Humans
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido