Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells.

Peters, Anna; Rabe, Philipp; Liebing, Aenne-Dorothea; Krumbholz, Petra; Nordström, Anders; Jäger, Elisabeth; Kraft, Robert; Stäubert, Claudia

Peters, Anna; Rabe, Philipp; Liebing, Aenne-Dorothea; Krumbholz, Petra; Nordström, Anders; Jäger, Elisabeth; Kraft, Robert; Stäubert, Claudia.

Afiliación

Peters A; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Rabe P; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Liebing AD; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Krumbholz P; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Nordström A; Swedish Metabolomics Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Linnaeus väg 6, 901 87 Umeå, Sweden.
Jäger E; Cedars-Sinai Medical Center, Department of Pathology, 8700 Beverly Blvd, 90048 Los Angeles, CA, USA.
Kraft R; Carl Ludwig Institute for Physiology, Faculty of Medicine, Leipzig University, Liebigstraße 27, 04103 Leipzig, Germany.
Stäubert C; Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany. Electronic address: claudia.staeubert@medizin.uni-leipzig.de.

Pharmacol Res ; 176: 106047, 2022 02.

Article en En | MEDLINE | ID: mdl-34968686

Asunto(s)

Macrófagos/metabolismo; Neutrófilos/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Receptores Nicotínicos/metabolismo; Células Cultivadas; Citocinas/metabolismo; Escherichia coli/crecimiento & desarrollo; Quinasas MAP Reguladas por Señal Extracelular/metabolismo; Humanos; Inmunidad Innata; Lactobacillales; Fagocitosis; Especies Reactivas de Oxígeno/metabolismo; Receptores Acoplados a Proteínas G/genética; Receptores Nicotínicos/genética

Palabras clave

1-(1-Methylethyl)−1H-benzotriazole-5-carboxylic acid (PubChem CID: 2736690); 3-Hydroxydecanoic acid (PubChem CID: 26612); 3-Hydroxyoctanoic acid (PubChem CID: 26613); 6-n-Octylaminouracil (PubChem CID: 10354234); D-(+)-3-Phenyllactic acid (PubChem CID: 643327); D-phenyllactic acid; Decanoic acid (PubChem CID: 2969); GPR84; Hydroxycarboxylic acid receptor 3; Lactic acid bacteria; Macrophages; Neutrophils

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores Nicotínicos / Receptores Acoplados a Proteínas G / Macrófagos / Neutrófilos Límite: Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania

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