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Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target.
Kroenke, Mark A; Barger, Troy E; Hu, Jenny; Miller, Mieke Jill; Kalenian, Kevin; He, Lidong; Hsu, Hailing; Bartley, Yessenia; Chow, Vincent Fung-Sing; Teixeira Dos Santos, Marcia Cristina; Sullivan, Barbara A; Cheng, Laurence E; Parnes, Jane R; Padaki, Rupa; Kuhns, Scott; Mytych, Daniel T.
Afiliación
  • Kroenke MA; Clinical Immunology, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
  • Barger TE; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States.
  • Hu J; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States.
  • Miller MJ; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, United States.
  • Kalenian K; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States.
  • He L; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States.
  • Hsu H; Inflammation Research, Amgen, Thousand Oaks, CA, United States.
  • Bartley Y; Global Safety, Amgen, Thousand Oaks, CA, United States.
  • Chow VF; Clinical Pharmacology, Modeling and Simulation, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
  • Teixeira Dos Santos MC; Clinical Biomarkers and Diagnostics, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
  • Sullivan BA; Clinical Biomarkers and Diagnostics, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
  • Cheng LE; Early Development, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
  • Parnes JR; Early Development, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
  • Padaki R; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States.
  • Kuhns S; Process Development, Attribute Sciences, Amgen, Thousand Oaks, CA, United States.
  • Mytych DT; Clinical Immunology, Translational Medicine, Amgen, Thousand Oaks, CA, United States.
Front Immunol ; 12: 782788, 2021.
Article en En | MEDLINE | ID: mdl-34970265
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos / Tolerancia Inmunológica / Formación de Anticuerpos / Complejo Antígeno-Anticuerpo Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos / Tolerancia Inmunológica / Formación de Anticuerpos / Complejo Antígeno-Anticuerpo Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos