HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy.
J Clin Invest
; 132(1)2022 01 04.
Article
en En
| MEDLINE
| ID: mdl-34981778
ABSTRACT
We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted intervention in the LEAP clinical trial. We identified an association between peanut-specific IgG4 and HLA-DQA1*0102 that was only observed in the presence of sustained oral peanut protein exposure. The association between IgG4 and HLA-DQA1*0102 was driven by IgG4 specific for the Ara h 2 component. Once peanut consumption ceased, the association between IgG4-specific Ara h 2 and HLA-DQA1*0102 was attenuated. The association was validated by observing expanded IgG4-specific epitopes in people who carried HLA-DQA1*0102. Notably, we confirmed the previously reported associations with HLA-DQA1*0102 and peanut allergy risk in the absence of oral peanut protein exposure. Interaction between HLA and presence or absence of exposure to peanut in an allergen- and epitope-specific manner implicates a mechanism of antigen recognition that is fundamental to driving immune responses related to allergy risk or protection.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Arachis
/
Inmunoglobulina G
/
Hipersensibilidad al Cacahuete
/
Alelos
/
Antígenos de Plantas
/
Albuminas 2S de Plantas
/
Cadenas alfa de HLA-DQ
/
Formación de Anticuerpos
Tipo de estudio:
Clinical_trials
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Invest
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos