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Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.
Lesniak, Robert K; Nichols, R Jeremy; Schonemann, Marcus; Zhao, Jing; Gajera, Chandresh R; Fitch, William L; Lam, Grace; Nguyen, Khanh C; Smith, Mark; Montine, Thomas J.
Afiliación
  • Lesniak RK; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford University, Stanford CA, 94305, USA; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Nichols RJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Schonemann M; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Zhao J; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Gajera CR; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Fitch WL; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Lam G; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Nguyen KC; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Smith M; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford University, Stanford CA, 94305, USA. Electronic address: mxsmith@stanford.edu.
  • Montine TJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA. Electronic address: tmontine@stanford.edu.
Eur J Med Chem ; 229: 114080, 2022 Feb 05.
Article en En | MEDLINE | ID: mdl-34992038
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Fármacos Neuroprotectores / Inhibidores de Proteínas Quinasas / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Indazoles Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Fármacos Neuroprotectores / Inhibidores de Proteínas Quinasas / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Indazoles Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos