Ophthalmic manifestations are associated with reduced tear lymphotoxin-α levels in chronic ocular graft-versus-host disease.
BMC Ophthalmol
; 22(1): 18, 2022 Jan 10.
Article
en En
| MEDLINE
| ID: mdl-35012541
ABSTRACT
PURPOSE:
To determine the role tear lymphotoxin-α (LT-α) in chronic ocular graft-versus-host disease (oGVHD).METHODS:
Twenty-two chronic oGVHD and 17 control tear samples were collected, and commercial test strips were used to detect LT-α concentrations. Concentration differences between patients with and without oGVHD were determined via Mann-Whitney U test. The correlation between LT-α levels and ophthalmic parameters was analyzed using Spearman's test.RESULTS:
The concentration of LT-α was significantly lower in oGVHD patients than in controls. LT-α levels were significantly correlated with OSDI, NIH eye score, T-BUT, and CFS among all participants. ROC analysis revealed that the area under the curve of LT-α was 0.847, and the cutoff value for chronic oGVHD diagnosis was 0.203 ng/mL.CONCLUSION:
Our study revealed the significant decrease of tear LT-α in oGVHD, and suggested LT-α as a promising marker for chronic oGVHD diagnosis.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Síndromes de Ojo Seco
/
Enfermedad Injerto contra Huésped
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
BMC Ophthalmol
Asunto de la revista:
OFTALMOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China