4EBP-1, translational initiation factor 4E binding protein-1; AILI, APAP-induced liver injury; ALT, alanine aminotransferase; APAP, acetaminophen; APAP-AD, APAP-adducts; Autophagy; CLEC-2, C-type lectin-like receptor; CYP2E1, cytochrome P450 2E; Coagulation; DILI; GCL, glutamate cysteine ligase; GSH, glutathione; H&E, hematoxylin and eosin; Hepatotoxicity; KC, Kupffer cells; KEAP1, Kelch-like ECH-associated protein-1; KIR, KEAP1-interacting region; KO, knockout; LC3, microtubule-associated light chain 3; Liver regeneration; Macrophage; NAC, N-acetylcysteine; NAPQI, N-acetyl-p-benzoquinone imine; NF-κB, nuclear factor-κB; NPCs, non-parenchymal cells; NQO1, NADPH quinone dehydrogenase 1; NRF2, nuclear factor erythroid 2-related factor 2; Platelet; S6, ribosomal protein S6 kinase; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; VWF, von Willebrand factor; WT, wild type