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The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situ.
Nachmanson, Daniela; Officer, Adam; Mori, Hidetoshi; Gordon, Jonathan; Evans, Mark F; Steward, Joseph; Yao, Huazhen; O'Keefe, Thomas; Hasteh, Farnaz; Stein, Gary S; Jepsen, Kristen; Weaver, Donald L; Hirst, Gillian L; Sprague, Brian L; Esserman, Laura J; Borowsky, Alexander D; Stein, Janet L; Harismendy, Olivier.
Afiliación
  • Nachmanson D; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
  • Officer A; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
  • Mori H; Division of Biomedical Informatics, Department of Medicine, University of California San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
  • Gordon J; Department of Pathology and Laboratory Medicine, Center for Immunology and Infectious Diseases, School of Medicine, University of California Davis, 2315 Stockton Blvd, Sacramento, CA, 95817, USA.
  • Evans MF; University of Vermont Cancer Center, 111 Colchester Avenue Main Campus, Main Pavillion, Level, 2, Burlington, VT, 05401, USA.
  • Steward J; Department of Biochemistry, University of Vermont, Burlington, VT, 05405, USA.
  • Yao H; University of Vermont Cancer Center, 111 Colchester Avenue Main Campus, Main Pavillion, Level, 2, Burlington, VT, 05401, USA.
  • O'Keefe T; Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, 05405, USA.
  • Hasteh F; Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, San Diego, CA, 92093, USA.
  • Stein GS; Institute for Genomic Medicine, University of California San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
  • Jepsen K; Department of Surgery, University of California San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
  • Weaver DL; Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, San Diego, CA, 92093, USA.
  • Hirst GL; Department of Pathology, University of California San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
  • Sprague BL; University of Vermont Cancer Center, 111 Colchester Avenue Main Campus, Main Pavillion, Level, 2, Burlington, VT, 05401, USA.
  • Esserman LJ; Department of Biochemistry, University of Vermont, Burlington, VT, 05405, USA.
  • Borowsky AD; Institute for Genomic Medicine, University of California San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
  • Stein JL; University of Vermont Cancer Center, 111 Colchester Avenue Main Campus, Main Pavillion, Level, 2, Burlington, VT, 05401, USA.
  • Harismendy O; Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, 05405, USA.
NPJ Breast Cancer ; 8(1): 6, 2022 Jan 13.
Article en En | MEDLINE | ID: mdl-35027560
ABSTRACT
Microenvironmental and molecular factors mediating the progression of Breast Ductal Carcinoma In Situ (DCIS) are not well understood, impeding the development of prevention strategies and the safe testing of treatment de-escalation. We addressed methodological barriers and characterized the mutational, transcriptional, histological, and microenvironmental landscape across 85 multiple microdissected regions from 39 cases. Most somatic alterations, including whole-genome duplications, were clonal, but genetic divergence increased with physical distance. Phenotypic and subtype heterogeneity was frequently associated with underlying genetic heterogeneity and regions with low-risk features preceded those with high-risk features according to the inferred phylogeny. B- and T-lymphocytes spatial analysis identified three immune states, including an epithelial excluded state located preferentially at DCIS regions, and characterized by histological and molecular features of immune escape, independently from molecular subtypes. Such breast pre-cancer atlas with uniquely integrated observations will help scope future expansion studies and build finer models of outcomes and progression risk.
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: NPJ Breast Cancer Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: NPJ Breast Cancer Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos